Drug-eluting stent coatings


J. E. Puskas,1 L. G. Munoz-Robledo,1 R. A. Hoerr,2 J. D. Foley,2 S. P. Schmidt,3 M. Evancho-Chapman,3 J. Dong,4 C. D. Fretland,4 and G. Haugstad4


1Department of Polymer Science, The University of Akron, Akron, OH 44325
2Division of Surgical Research, Summa Health System, Akron, OH 44304
3Nanocopoeia, Inc., 1246 West University Avenue, Suite 463, St. Paul, Minnesota 55104
4Characterization Facility, University of Minnesota, Minneapolis, Minnesota 55455

Abstract

This paper reviews the development of coronary stents from a polymer scientistís view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene-b-isobutylene-b-styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug-eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Our group has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D_SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc.TM) was used to coat test coupons and coronary stents with selected D_SIBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release pro?les were in?uenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer-drug mixture.