Table 1
Poisonous Gases

The gases on this list are either on the Department of Transportation's Category 1 list, or the Linde Specialty Gases company's Group 6 - Very Poisonous list. These chemicals are highly toxic gases at ambient temperature and pressure. They have an extremely high potential for causing significant harm if not adequately controlled.

Arsine Boron trichloride Chlorine pentafluoride
Chlorine trifluoride Cyanogen Cyanogen chloride
Diborane Dinitrogen tetroxide Fluorine
Germane Hydrogen selenide Nitric oxide
Nitrogen dioxide Nitrogen trioxide Nitrosyl chloride
Oxygen difluoride Phosgene Phosphine
Phosphorus pentafluoride Selenium hexafluoride Stibine
Sulfur tetrafluoride Tellurium Hexafluoride Tetraethyldithiopyrophosphate

Table 2
Shock Sensitive Chemicals

The classes of chemicals listed below may explode when subjected to shock or friction. Therefore users must have appropriate laboratory equipment, information, knowledge and training to use these compounds safely.

Note: Perchloric acid must be used only in specially-designed perchloric acid fume hoods that have built-in wash down systems to remove shock-sensitive deposits. Before purchasing this acid, laboratory supervisors must arrange for use of an approved perchloric acid hood.

Table 3
Pyrophoric Chemicals

The classes of chemicals listed below will readily oxidize and ignite spontaneously in air. Therefore, users must demonstrate to the department that they have the appropriate laboratory equipment, information, knowledge and training to use these compounds safely.

Table 4
Peroxide-Forming Chemicals

The chemicals listed below can form explosive peroxide crystals on exposure to air, and therefore require special handling procedures after the container is opened. Some of the chemicals form peroxides that are violently explosive in concentrated solution or as solids, and therefore shouldneverbe evaporated to dryness. Others are polymerizable unsaturated compounds and can initiate a runaway, explosive polymerization reaction. All peroxidizable compounds should be stored away from heat and light. They should be protected from physical damage and ignition sources. A warning label should be affixed to all peroxidizable materials to indicate the date of receipt and the date the container was first opened. Due to these special handling requirements, users must have the appropriate laboratory equipment, information, knowledge and training to use these compounds safely.

Severe Peroxide Hazard with Exposure to Air
(discard within 3 months from opening) Peroxide Hazard on Concentration
Do not distill or evaporate without first testing for the presence of peroxides (discard or test for peroxides after 6 months) Hazard of Rapid Polymerization Initiated by Internally-FormedPeroxides
(discard or test for peroxides after 6 months)

chloroprene (2-chloro-1,3-butadiene)

(discard after 12 months)

Table 5
Carcinogens, Reproductive Toxins or Highly Toxic Chemicals

The chemicals listed below are extremely hazardous. Workers must have knowledge of the dangers of these chemicals prior to use, and documentation of training in safe working procedures.

Biologically active compounds

Castor bean (Ricinus communis) lectin: Ricin A, Ricin B, RCA toxins

Diisopropyl fluorophosphate: highly toxic cholinesterase inhibitor; the antidote, atropine sulfate and 2-PAM (2-pyridinealdoxime methiodide) must be readily available

Jaquirity bean lectin (Abrus precatorius)

N-methyl-N'-nitro-N-nitrosoguanidine: carcinogen (this chemical forms explosive compounds upon degradation)

Phalloidin from Amanita Phalloides: used for staining actin filaments

Retinoids: potential human teratogens

Streptozotocin: potential human carcinogen

Urethane (ethyl carbamate): an anesthetic agent, potent carcinogen and strong teratogen, volatile at room temperature

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